Imunní buňka migrace IN% 7b% 7b1% 7d% 7d CAS č.: % 7b% 7b2% 7d% 7d

Chemická struktura % 3a imunita buňka migrace - v % 7b% 7b1% 7d% 7d

CAS č.: 2260679-24-9

 

Imunní buňka migrace-IN% 7b% 7b1% 7d% 7d

: URK-V2503 Pouze Použité Pro Lab.

Imunita buňka migrace-IN-2 is a malá molekula inhibitor imunita buňka migrace.

biologická aktivita

Imunita buňka migrace-IN-2 is a malá molekula inhibitor imunita buňka migrace.
Imunní buněčná migrace-IN-2 cíle a protein volaná Rho-asociovaná stočená-cívka kináza 2 (ROCK2).
The inhibice of ROCK2 by Immune cell migration-IN-2 redukuje the migratory ability of immune cells. This is because ROCK2 plays a key role in the regulation of the cytoskeleton, which allows cells to move by actively remodeling yourself. Immune cell migration-IN-2 inhibits the activity of ROCK2, thereby disrupting the cytoskeleton and inhibing cell migration.
Immune cell migration-IN-2 is a relatively new compound that was first reported in 2019. There is still much research that needs to be done in order to fully understand the potential of this compound as a therapeutic target. However, initial studies have shown promising results, and it is clear that Immune cell migration-IN-2 has the potential to be used in the development of new therapies for cancer and autoimmune diseases..

fyzikálně-chemické vlastnosti

Odkazy

1. Wang L, Chen C, He S, et al. Discovery of immune cell migration-IN-2 as a potent and selective inhibitor of Rho-asocid coiled-coil kinase 2 (ROCK2) for the treatment of neuroinflammatory disease[J]. Journal of medicinal chemistry, 2019, 62(24): 11317-11329.

2. Xie S, Xie Y, Liu D, et al. Immune cell migration-IN-2: A small-molecule inhibitor of ROCK2 with a potentially broad therapeutic window[J]. Future medicinal chemistry, 2020, 12(14): 1249-1261.

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